Synthesis of locked S-type and locked N-type uridine monomer units for incorporation in 2'-5' RNA:3'-5'RNA duplexes
نویسندگان
چکیده
منابع مشابه
the investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes
Locked nucleic acids (LNA; symbols of bases, +A, +C, +G, and +T) are introduced into chemically synthesized oligonucleotides to increase duplex stability and specificity. To understand these effects, we have determined thermodynamic parameters of consecutive LNA nucleotides. We present guidelines for the design of LNA oligonucleotides and introduce free online software that predicts the stabili...
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abstract in written mode of language, metadiscourse markers are used commonly to help writers in general and academic writers in particular to produce coherent and professional texts. the purpose of the present study was to compare introduction sections of applied linguistics and physics articles regarding their use of interactive and interactional metadiscourse markers based on the model pro...
15 صفحه اولA 5-year evaluation and results of treatment of chronic locked dislocations of the shoulder joint
Abstract Background: Chronic neglected dislocation of the shoulder joint can be defined as a neglected dislocation for more than a 3 week period. However, it has been shown that the negligence could range from a 24 hour period to 6 months1. Depending on age, signs, symptoms, etiology and types of dislocation, conservative treatment or surgical intervention could be considered. Methods: In t...
متن کاملTwo carbocyclic locked nucleic acid analogues give structural information about the role of hydration in A-type duplexes.
Two locked nucleic acid (LNA) analogues with three-carbon 2'-4' linkages, saturated or unsaturated, are synthesized using a ring-closing metathesis based strategy. Strongly stabilized duplexes with complementary RNA and slightly destabilized duplexes with complementary DNA are observed. CD-spectroscopy indicates a less pronounced shift toward A-type duplexes compared to LNA. These results combi...
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ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2008
ISSN: 0261-3166,1746-8272
DOI: 10.1093/nass/nrn097